BD and A*STAR collaborate to advance ultrahigh dimensional analysis in flow cytometry for immunology research

BD and A*STAR collaborate to advance ultrahigh dimensional evaluation in movement cytometry for immunology analysis

SINGAPORE, March 28, 2023 /PRNewswire/ — Becton Dickinson Holdings Pte Ltd (BD), a world chief in life science applied sciences, and the Company for Science, Know-how and Analysis (A*STAR), of Singapore main public sector analysis and growth company, have introduced an expanded analysis partnership that can give attention to deep immunophenotyping of human tissue utilizing spectral movement cytometry panels to unearth discoveries that may be translated into optimistic well being outcomes.

Spectral movement cytometry is the most recent development in movement cytometry that enables researchers to broaden the variety of detectable parameters. An expanded spectral flux panel dimension permits for the maximization of biologically related data from a restricted beginning materials. With the elevated depth of immunophenotyping comes the power to characterize affected person immune standing extra comprehensively, each broadly to seize a number of cell sorts throughout completely different lineages, and in depth in chosen cell populations.

In a earlier partnership between the A*STAR Singapore Immunology Community (A*STAR SIgN) and BD signed in 2016, an entire leukocyte panel comprising 35 markers with 26 fluorophores was generated utilizing the sentinel method. This partnership validated BD Biosciences’ prototype reagents and expanded the scope of organic information that may very well be acquired through movement cytometry. This has efficiently led to the fast monitoring of different high-parameter movement cytometry panels which were used to review responses to immunotherapy, in addition to the human immune response to COVID-19. With this earlier partnership as a foundation, the analysis group goals to broaden the potential panel dimension as much as 43 markers with out utilizing the sentinel method utilizing specialised tools for BD cell evaluation.

Leveraging the scientific know-how of A*STAR and BD, two spectral movement cytometry panels for deep immunophenotyping of human samples utilizing marker-fluorophore combos can even be designed and optimized. These panels will give attention to markers of curiosity in immunology and most cancers and contribute to A*STAR’s translational analysis within the fields of immuno-oncology and pediatric allergy.

By means of this collaboration, the analysis group goals to attain the best high quality within the acquisition of single-cell organic information acquired within the house of high-dimensional polychromatic movement cytometry panels, whereas additionally making information evaluation considerably simpler with a barrier of enter and decrease know-how wanted. These panels will function the inspiration for constructing different associated movement panels, cut back the event time required to create new high-dimensional spectral panels, in addition to enhance the consistency and reproducibility of movement cytometry information for the A*STAR SIgN and ecosystem of analysis.

The professor. Lam Kong Peng, government director of A*STAR SIgN, stated, “Constructing on our earlier collaboration with BD Bioscience in high-dimensional movement cytometry, we’re excited to dive deeper into the immune system in our most cancers and illness research.” allergic reactions to advance well being discoveries that can profit them Singapore and past.”

“This collaboration will give attention to utilizing the most recent advances in spectral movement cytometry, such because the BD FACSymphonyTM extension A5 SE Cell Analyzer unit, to carry out deep immunophenotyping of human tissues, with the purpose of constructing discoveries that may enhance well being outcomes. We’re excited to proceed our partnership with A*STAR SIgN and contribute to the fields of immuno-oncology and pediatric allergy,” he stated. Bob BalderasVice President of Organic Sciences, BD.

About BD

BD is without doubt one of the largest world medical know-how firms on the planet and it’s transferring the world of well being aheadTM extension bettering medical discovery, diagnostics and care supply. The corporate helps heroes on the frontline of healthcare by growing progressive applied sciences, companies and options that assist advance each scientific remedy for sufferers and the scientific course of for healthcare professionals. BD and its 77,000 staff have a ardour and dedication to assist enhance the protection and effectivity of the doctor care supply course of, allow laboratory scientists to precisely detect illness, and advance the capabilities of researchers to develop the following era of diagnostics and therapeutics. BD has a presence in just about each nation and companions with organizations world wide to handle a few of the most difficult world well being points. By working intently with prospects, BD can assist enhance outcomes, cut back prices, improve effectivity, enhance security, and broaden entry to healthcare. For extra details about BD, go to or join with us on LinkedIn at and Twitter @BDandCo.

About A*STAR Singapore Immunology Community (A*STAR SIgN)

Established in 2006, the mission of the A*STAR Singapore Immunology Community (A*STAR SIgN) is to advance analysis in human translational immunology, contribute to scientific information, and make progressive discoveries in immune-based therapies and applied sciences in a method to enhance life and foster additional socio- financial development. A*STAR SIgN is residence to roughly 150 researchers together with famend Principal Investigators, postdoctoral fellows and assist workers working beneath the route of Professor Lam Kong Peng. A*STAR SIgN additionally helps nurture and retain analysis expertise to assist construct the analysis ecosystem in Singapore.

The analysis actions of A*STAR SIgN are usually divided into three principal areas of curiosity: immuno-oncology, immune potential, regulation and getting old, and immuno-pathology. Our analysis groups are supported by a powerful in-house cluster of cutting-edge know-how platforms. By means of collaborations with hospitals and firms, A*STAR SIgN can also be dedicated to translating analysis findings into scientific and business purposes. All in all, A*STAR SIgN is working to contribute to an enriching and vibrant analysis surroundings in Singapore. For extra data on A*STAR SIgN, visIt

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In regards to the Company for Science, Know-how and Analysis (A*STAR)

The Company for Science, Know-how and Analysis (A*STAR) is of Singapore main analysis and growth company within the public sector. By means of open innovation, we collaborate with our companions in each the private and non-private sectors for the advantage of the financial system and society. As a science and know-how group, A*STAR bridges the hole between academia and trade. Our analysis creates financial development and jobs for Singaporeand improves lives by bettering social outcomes in healthcare, city residing and sustainability. A*STAR performs a key position in nurturing scientific expertise and leaders for the broader analysis neighborhood and trade. A*STAR’s analysis and growth actions span the biomedical sciences to bodily sciences and engineering, with analysis entities primarily positioned in Biopolis and Fusionopolis. For present information, go to

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For extra data, please contact:

Keefe Chee
Head of Phase Advertising, Life Sciences
Becton Dickinson Holdings Pte Ltd
Cell: (65) 9199 3584



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SOURCE BD (Becton, Dickinson and Firm)

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